Turk Kardiyol Dern Ars. 2007; 35(6): 347-353
The I/D polymorphism of the angiotensin converting enzyme gene as a risk factor for ischemic stroke in patients with essential hypertension in Kyrgyz population
, Abdimutalip Halmatov1
, Oleg Pak2
, Tatyana Romanova1
, Elena Kim2
, Natalia Cheskidova1
, Almaz Aldashev2
, Ainagul Dzhumagulova11
National Center Of Cardiology And Internal Medicine2
Institute Of Molecular Biology And Medicine
OBJECTIVES We investigated the association of the I/D polymorphism of the angiotensin converting enzyme (ACE) gene with essential hypertension (EH) and ischemic stroke in Kyrgyz male subjects.
STUDY DESIGN The study included a total of 313 Kyrgyz men, including 180 patients with uncomplicated EH, 69 patients with EH complicated by ischemic stroke, and 64 healthy age-matched controls. All the subjects underwent I/D genotyping and determination of serum ACE activity. Ambulatory blood pressure (BP) monitoring and carotid ultrasound (51 patients) were also performed in patients with EH.
RESULTS The mean ACE concentration was 23.3±0.7 mU/ml/min for II, 32.2±0.9 mU/ml/min for ID, and 38.8±2.3 mU/ml/min for DD genotypes. The ID and DD genotypes were associated with significantly higher ACE levels compared to the II genotype (p<0.01 and p<0.0001, respectively). The frequency of the DD genotype in EH patients with ischemic stroke was more than two-fold greater than those with uncomplicated EH (0.31 vs 0.13, p<0.02), and nearly four-fold greater than the control group (0.31 vs 0.09, p<0.02). Patients with ischemic stroke had the highest frequency of the D allele compared to EH patients without stroke and controls (0.56 vs 0.36 and 0.29 respectively, p<0.001). Patients with the DD genotype differed significantly from those with the II or ID genotypes with greater variability of systolic and diastolic BP, more common abnormal night BP profile, and increased carotid intima-media thickness.
CONCLUSION In the Kirghiz population, the presence of the DD genotype is associated with higher ACE levels and increased risk for ischemic stroke as a complication of EH.
Cerebrovascular accident, DNA/analysis, genotype; hypertension, pulmonary/genetics; Kyrgyzstan; peptidyl-dipeptidase A/genetics; polymorphism, genetic; risk factors
How to cite this article
Andrey Polupanov, Abdimutalip Halmatov, Oleg Pak, Tatyana Romanova, Elena Kim, Natalia Cheskidova, Almaz Aldashev, Ainagul Dzhumagulova. The I/D polymorphism of the angiotensin converting enzyme gene as a risk factor for ischemic stroke in patients with essential hypertension in Kyrgyz population. Turk Kardiyol Dern Ars. 2007; 35(6): 347-353
Corresponding Author: Tatyana Romanova, Kyrgyzstan