Turk Kardiyol Dern Ars. Ahead of Print: TKDA-01578 | DOI: 10.5543/tkda.2018.TKDA-01578
The relationship between echocardiographic epicardial adipose tissue and P-wave dispersion and corrected QT interval
, Serhat Emre Şentürk2
, Hazar Harbalıoğlu2
, Ahmet Oytun Baykan21
Medline Adana Hospital, Department of Cardiology, Adana, Turkey.2
University of Health Sciences, Adana Numune Training and Research Hospital, Department of Cardiology, Adana, Turkey.
OBJECTIVE Epicardial adipose tissue (EAT) secretes various pro-inflammatory and atherogenic substances that have several effects on the heart. In this study, we aimed to evaluate the association between EAT thickness and both P-wave dispersion (Pd) and corrected QT (QTc) interval, as simple, non-invasive tools of pro-arrhythmia on surface electrocardiogram.
METHODS This retrospective observational study included 216 patients who had normal coronary arteries at coronary angiography. Each patient underwent 12-derivation electrocardiography to measure Pd and QTc interval and transthoracic echocardiography to measure EAT thickness. Patients were divided into two groups according to the median EAT value (EAT low group <5.35mm and EAT high group ≥ 5.35mm).
RESULTS P-wave dispersion (p=0.001) was significantly increased in the EAT high group compared to the EAT low group. However, QTc interval (p=0.004) was significantly increased in the latter. Median left ventricular end-diastolic diameter (p=0.033), mean left ventricular end-systolic diameter (p=0.039) and mean left atrial diameter (p=0.012) were significantly increased in the EAT high group compared to the EAT low group. Multiple logistic regression analysis with backward method revealed that leukocyte count (OR=1.000, 95% CI: 1.000 to 1.000, p=0.001), Pd (OR=1.1026, 95% CI: 1.010 to 1.043, p=0.002), QTc interval (OR=0.988, 95% CI: 0.979 to 0.997, p=0.009) and left ventricular ejection fraction (OR=0.922, 95% CI: 0.859 to 0.989, p=0.023) were independently associated with high EAT thickness.
CONCLUSION Echocardiographic end-diastolic EAT thickness on the free wall of the right ventricle is associated with Pd and QTc interval in patients with normal coronary arteries.
Epicardial adipose tissue, P-wave dispersion, corrected QT interval
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Corresponding Author: Alaa Quisi, Türkiye